现任中国农业科学院兰州兽医研究所口蹄疫防控技术团队首席,2015年入选中国农业科学院“青年英才计划”A类人才、2016年入选科技部中青年科技创新领军人才，2017年入选国家第三批“万人计划”,2018年入选中国农业科学院“农科英才”B类人才，获“楚天学者计划”特聘教授、渤海英才-杰出贡献专家等荣誉称号，2020年获甘肃省拔尖领军人才第一层次。

主要致力于动物病毒病原生物学及以病毒为纳米生物材料的多学科交叉研究，建立了动物病毒样颗粒（VLPs）组装及优化技术平台，获得国内最先报道的原核表达系统组装的口蹄疫VLPs。一类新兽药注册证书2项、获23项中国发明专利、4项国际专利，4份生物安全证书、2份临床批件，并先后获中国专利优秀奖、甘肃省专利一等奖和甘肃省专利发明人奖、第九届大北农科技奖创意奖、中国农科科学院科技奖及中国农业科学院成果转化奖等；主持国家级项目5项（其中重点研发课题1项，国家自然基金3项、外专局引智项目2项）及10多项省部级/院级科研项目；分别以第一及通讯作者在Protein and Cell，mBIO，J Immunol， J Virol， Nanoscale，Nanomedicine：NBM，Cell and Death Disease，RNA biology等优势期刊收录文章70多篇，其中2篇分别为Nanoscale、J Virol封面文章；以主编编著《动物病毒样颗粒技术》（中国科学出版社）、以副主编编著《天然分子免疫学》（科学出版社）、以编委参编译著《默克兽医手册（第十版）》（中国农业出版社）等5部专著;为中国畜牧兽医学会生物技术学分会委员、甘肃省免疫学会感染免疫与防治专业委员会委员、中国畜牧兽医学会口蹄疫学分会理事、中国畜牧兽医学会兽医公共卫生分会委员、中国生物医药学会核酸疫苗分会、Journal of Molecular Pharmaceutics & Organic Process Research编委

第一作者或通讯作者SCI论文70余篇，第一或通讯作者中文核心期刊20余篇

Tang J, Abdullah SW, Li P, Wu J, Pei C, Mu S, Wang Y, Sun S, Guo H*.Heat Shock Protein 60 Is Invoived in Viral Replication Complex Formation and Facilitates Foot and Mouth Viral Nonstructural Proteins 3A and 2C.mBio. 2022 Oct 26;13(5):e0143422.*通讯作者

Zhidong Teng, Fengping Hou, Manyuan Bai, Jiajun Li,Jun Wang, Jinen Wu, Jiaxi Ru, Mei Ren, Shiqi Sun, Huichen Guo*.The biomineralization of virus-like particles by metal-organic framework nanoparticles enhances the thermostability and immune responses of the vaccine.J Mater Chem B. 2022,10(15):2853-2864.*通讯作者

Hou F, Teng Z, Ru J, Liu H, Li J, Zhang Y, Sun S, Guo H*.Flower-like mesoporous silica nanoparticles as an antigen delivery platform to promote systemic immune response 

Nanomedicine. NBM .2022 Feb 16;42:102541.*通讯作者

Zhang Y, Wang R, Bai M, Wang X, Dong H, Li J, Mu S, Miao H, Song J, Sun S, Guo H*.Development of a competitive ELISA method based on VLPs detecting the antibodies of serotype A FMDV.J Virol Methods. 2022,300:114406*通讯作者

Yuying Cao, Li Yuan, Shunli Yang, Youjun Shang, Bin Yang, Zhizhong Jing, Huichen Guo*,shuanghui Yin。Establishment and application of a solid-phase blocking ELISA method for the detection of antibodies against classical swine fever virus。J Vet Sci,2022，23（2）:e32。*通讯作者

Dong H, Liu P, Bai M, Wang K, Feng R, Zhu D, Sun Y, Mu S, Li H, Harmsen M, Sun S, Wang X, Guo H*。Structural and molecular basis for foot-and-mouth disease virus neutralization by two potent protective antibodies.Protein Cell.2021(Pt 3)*通讯作者

Dong H, Lu Y, Zhang Y, Mu S, Wang N, Du P, Zhi X, Wen X, Wang X, Sun S, Zhang Y, Guo H*.A heat-induced Mutation on VP1 of FMDV Serotype O Enhanced Capsid Stability and the Immunogenicity.J Virol.2021 May 19;JVI.00177-21.*通讯作者.

Teng Z, Sun S, Luo X, Zhang Z, Seo H, Xu X, Huang J, Dong H, Mu S, Du P, Zhang Z, Guo H. Bi-functional gold nanocages enhance specific immunological responses of foot-and-mouth disease virus-like particles vaccine as a carrier and adjuvant.Nanomedicine-Nanotechnology Biology and Medicine.2021 Apr;33:102358*通讯作者

Han S, Wang X, Guan J, Wu J, Zhang Y, Li P, Liu Z, Abdullah SW, Zhang Z, Jin Y, Sun S, Guo H*.Nucleolin promotes IRES-driven translation of foot-and-mouth disease virus by supporting the assembly of translation initiation complexes.J Virol.2021 Jun 10;95(13):e0023821.*通讯作者

Junyong Guan, Shichong Han1, Jin’en Wu, Yun Zhang, Manyuan Bai,Sahibzada Waheed Abdullah, Shiqi Sun ，Huichen Guo*.Ribosomal Protein L13 Participates in Innate Immune Response Induced by Foot-and-Mouth Disease Virus.Frontiers in Immunology. 2021 May 20;12:616402.*通讯作者

Bai M, Wang R, Sun S, Zhang Y, Dong H, Guo H*.Development and validation of a competitive ELISA based on virus-like particles of serotype Senecavirus A to detect serum antibodies.AMB Express.2021 Jan 6;11(1):7.*通讯作者

Mengnan Guo, Jiajun Li, Zhidong Teng, Mei Ren, Hu Dong, Yun Zhang, Jiaxi Ru, Ping Du, Shiqi Sun, Huichen Guo *Four kinds of biomineralization improve thermostability and immunogenicity of foot-and-mouth disease virus-like particles vaccine Authors.Vaccines.2021, 9, 891 *通讯作者

Jin'en Wu, Zhihui Zhang Zhidong Teng, Sahibzada Waheed Abdullah1, Shiqi Sun, Huichen Guo*, Sec62 regulates endoplasmic reticulum stress and autophagy balance to affect foot-and- mouth disease virus replication Front. Cell. Infect. Microbiol. 2021,11:707107.*通讯作者

Sahibzada Waheed Abdullah, Jin'en Wu, Yun Zhang, Manyuan Bai, Junyong Guan, Xiangtao Liu, Shiqi Sun , Huichen Guo*. DDX21, a host restriction factor of FMDV-IRES dependent translation and replication Viruses 2021, 13, 1765.*通讯作者

Zhi, XY; Zhang, Y; Sun, SQ; Zhang, ZH; Dong, H.; Luo, X.; Wei, YQ; Lu, ZJ; Dou, YX; Wu, R; Jiang, ZF; Weng, CJ; Seo, HS; Guo, HC *NLRP3 inflammasome activation by Foot-and-mouth disease virus infection mainly induced by viral RNA and non-structural protein 2B.RNA Biol.2020, 17(3): 335-349*通讯作者

Mu SY#, Sun SQ#, Dong H, Bai MY, Zhang Y, Teng ZD, Ren M, Yin SH, Guo HC*. Potent Protective Immune Responses to Senecavirus Induced by Virus-Like Particle Vaccine in Pigs. Vaccines. 2020, 8, 532. （IF: 4.718）.*通讯作者

Hou FP#, Bai MY, Zhang Y, Liu HY, Sun SQ, Guo HC*. Fluorescent immunochromatographic assay for quantitative detection of the foot-and-mouth disease virus serotype O antibody. Microchemical Journal. 2020, 155, 104704（IF: 3.594）.*通讯作者

Hou FP#, Liu HY, Zhang Y, Gao ZD, Sun SQ, Tang Y, Guo HC*. Upconversion nanoparticles-labelled immunochromatographic assay for quantitative biosensing. New J. Chem. 2020, 44, 15498（IF: 3.288）.*通讯作者

Sahibzada WA#, Han SC, Wu JE, Zhang Y, Bai MY, Jin Y, Zhi XY, Guan JY, Sun SQ*, Guo HC*. The DDX23 Negatively Regulates Translation and Replication of Foot-and-Mouth Disease Virus and Is Degraded by 3C Proteinase. Viruses. 2020, 12(12), 1348.（IF: 3.816）.*通讯作者

Han SC#,Sun SQ#, Li PH, Liu Q, Zhang ZH, Dong H, Sun MM, Wu WX, Wang XJ*, Guo HC*.Ribosomal Protein L13 Promotes IRES-Driven Translation of Foot-and-Mouth Disease Virus in a Helicase DDX3-Dependent Manner.J Virol. 2020, 94(2): e01679-19.*通讯作者

Han SC#, Mao LJ#, Liao Y#, Sun SQ, Zhang ZH, Mo YX, Liu HY, Zhi XY, Lin SM, Seo HS, Guo HC*Sec62 Suppresses Foot-and-Mouth Disease Virus Proliferation by Promotion of IRE1 α-RIG-I Antiviral Signaling.J Immunol, 2019, 203(2):429-440*通讯作者

Bai MY#, Dong H#, Su X, Jin Y, Sun SQ, Zhang YP, Yang YS, Guo HC*.Hollow mesoporous silica nanoparticles as delivery vehicle of foot‐and‐mouth disease virus‐like particles induce persistent immune responses in guinea pigs.J Med Virol, 2019, 91: 941-948*通讯作者

Du P #, Liu RH#, Sun SQ, Dong H, Zhao RB, Tang RK,Dai JW, Yin H,Luo JX, Liu ZX*, Guo HC*.Biomineralization improves the thermostability of foot-and-mouth disease virus-like particles and the protective immune response induced.Nanoscale. 2019,11(47):22748-22761.*通讯作者（封面文章）

Qian J#, Gong DY, Teng ZD, Wang JM, Cao T, Iqbal K, Liu W, Iqbal A, Qin WW*, Guo HC*. 2-Vinylfuran substituted BODIPY H2S fluorescent turn on probe based on hydrolysis of furfural and nucleophilic addition of double bond. Sensors and Actuators: B. Chemical,2019, 297: 126712. （IF:6.393）*通讯作者

Qian J#, Gong DY, Ru JX, Guo YL, Cao T, Liu W, Iqbal A, Iqbal K, Qin WW*, Guo HC*.A naphthalimide-based lysosome-targeting fluorescent probe for the selective detection and imaging of endogenous peroxynitrite in living cells.Analytical and Bioanalytical Chemistry, 2019, 411: 3929-3939.*通讯作者

Cao T#, Teng ZD, Gong DY, Qian J, Liu W, Iqbal K, Qin WW*, Guo HC*.A ratiometric fluorescent probe for detection of endogenous and exogenous hydrogen sulfide in living cells.Talanta2019, 198: 185-192*通讯作者

Li XR#, Ma H, Qian J, Cao T, Teng ZD, Iqbal K, Qin WW*, Guo HC*.Ratiometric fluorescent probe based on ESIPT for the highly selective detection of cysteine in living cells.Talanta, 2019, 194: 717-722.*通讯作者

Liu ZJ#, Ru JX#, Sun SQ, Teng ZD, Dong H, Song P, Yang YS*, Guo HC*.Uniform dendrimer-like mesoporous silica nanoparticles as a nano-adjuvant for foot-and-mouth disease virus-like particle vaccine.J. Mater. Chem. B, 2019, 7, 3446-3454.*通讯作者

Zhang YP*#, Ma JM, Yang YS*, Ru JX, Liu XY, Ma Y, Guo HC*.Synthesis of nitrogen-doped graphene quantum dots (N-GQDs) from marigold for detection of Fe3+ ion and bioimaging.Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2019, 217: 60-67.*通讯作者

Wang JM#, Qian J, Teng ZD, Cao T, Gong DY, Liu W, Cao YP, Qin WW*, Guo HC*, Iqbal A*.Self-Assembling Ratiometric Fluorescent Micelle Nanoprobe for Tyrosinase Detection in Living Cells.ACS Appl. Nano Mater, 2019, 2: 3819−3827.*通讯作者

Liu W#, Cao YP, Wang WZ, Gong DY, Cao T, Qian J, Iqbal K, Qin WW*, Guo HC*. Mechanochromic luminescent covalent organic frameworks for highly selective hydroxyl radical detection. Chem. Commun, 2019, 55: 167-170. （IF:6.164）.*通讯作者

Teng Z#, Sun S#, Chen H, Huang J, Du P, Dong H, Xu X, Mu S, Zhang Z, Guo H*.Golden-star nanoparticles as adjuvant effectively promotes immune response to foot-and-mouthdisease virus-like particles vaccine.Vaccine,2018, 36: 6752–6760.*通讯作者

Cao T, Gong D, Han SC, Iqbal A, Qian J, Liu W, Qin W*, Guo H*.BODIPY-based fluorescent sensor for imaging of endogenous formaldehyde in living cells.Talanta, 2018, 189: 274-280.*通讯作者

Gong D，Ru J，Cao T，Qian J，Liu W，Iqbal A，Liu W，Qin W*, Guo H*.Two-stage ratiometric fluorescent responsive probe for rapid glutathione detection based on BODIPY thiol-halogen nucleophilic mono-or disubstitution.Sensors and Actuators, B: Chemical，2018，258：72-79.*通讯作者

lqbal A，lqbal K，Xu L，Li B，Gong D，Liu X，Guo Y，Liu W，Qin W*, Guo H*.Heterogeneous synthesis of nitrogen-doped carbon dots prepared via anhydrous citric acid and melamine for selective and sensitive turn on-off-on detection of Hg (II), glutathione and its cellular imaging.Sensors and Actuators, B: Chemical，2018，255：1130-1138.*通讯作者

Zhi XY, Lv JL, Wei YQ, Gao Y, Du P, Chang YY, Zhang Y, Wu R*, Guo HC*.Foot-and-mouth disease virus infection stimulates innate immune signaling in the mousemacrophage RAW 264.7 cells.Can J Microbiol. 2018, 64(2)155-166.*通讯作者

Yang YS*, Ma SS, Zhang YP*, Ru JX,  Liu XY, Guo HC*.A novel biphenyl-derived salicylhydrazone Schiff base fluorescent probes for identification of Cu2+ and application in living cells.Spectrochim Acta A Mol Biomol Spectrosc. 2018 , 199:202-208.*通讯作者

Zhang YP*, Xue QH, Yang YS*, Liu XY, Ma CM, Ru JX, Guo HC*.A chromene pyrazoline derivatives fluorescent probe for Zn2+detection in aqueous solution and living cells.Inorganica Chimica Acta,2018,479,128-134.*通讯作者

Yang YS, Ma CM, Zhang YP,* Xue QH, Ru JX, Liu XY, Guo HC*.A highly selective "turn-on" fluorescent sensor for zinc ion based on a cinnamyl pyrazoline derivative and its imaging in live cells.Anal. Methods, 2018,10, 1833-1841.*通讯作者

Xuxu Fan, Shichong Han, Dan Yan, Yuan Gao, Yanquan Wei, Xiangtao Liu, Ying Liao*,Huichen Guo*,and Shiqi Sun*.Foot-and-mouth disease virus infection suppresses autophagy and NF-кB antiviral responses via degradation of ATG5-ATG12 by 3Cpro.Cell Death and Disease. 2017, 8: e2561.*通讯作者

Dan Yan#, Zhidong Teng#, Shiqi Sun#, Shan Jiang, Hu Dong, Yuan Gao, Yanquan Wei, Wenwu Qin, Xiangtao Liu*,Hong Yin*, Huichen Guo*.Foot-and-mouth Disease Virus-like Particles as Integrin-Based Drug Delivery System Achieve Targeting Anti-tumor Efficacy.Nanomedicine: NBM, 2017, 13: 1061-10706.*通讯作者

Deyan Gong, Xiangtao Zhu, Yuejun Tian, Shi-Chong Han, Min Deng, Anam Iqbal, Weisheng Liu, Wenwu Qin*, and Huichen Guo*.Phenylselenium-Substituted BODIPY Fluorescent Turn-off Probe for Fluorescence Imaging of Hydrogen Sulfide in Living Cells.Anal. Chem. 2017, 89: 1801-1807.*通讯作者

Du P, Sun S, Dong J, Zhi X, Chang Y, Teng Z, Guo H*, Liu Z*.Purification of foot-and-mouth disease virus by heparin as ligand for certain strains.J Chromatogr B, 2017, 1049-1050: 16-23.*通讯作者

Guo HC#, Huang M, Yuan Q, Wei YQ, Gao Y, Mao LJ, Gu LJ, Tan YW, Zhong YX, Liu DX*, Sun SQ*.The Important Role of Lipid Raft-Mediated Attachment in the Infection of Cultured Cells by Coronavirus Infectious Bronchitis Virus Beaudette Strain. PLoS One,2017, 12(1): e0170123. （IF: 2.806）.第一作者

Gong DY#, Cao T, Han SC, Zhu XT, Iqbal A, Liu WS, Qin WW*,Guo HC*. Fluorescence enhancement thermoresponsive polymer luminescent sensors based on BODIPY for intracellular temperature. Sensors and Actuators B:Chemical, 2017, 252: 577-583. （IF: 5.401）*通讯作者

Deng M, Gong D, Han S, Zhu X, Iqbal A, Liu W, Qin W*, Guo H*.BODIPY based phenylthiourea derivatives as highly selective MeHg+ and Hg2+ ions fluorescent chemodosimeter and its application to bioimaging.Sensors and Actuators B 243 (2017) 195–202.*通讯作者

Deyan Gong, ShiChong Han, Anam Iqbal, Jing Qian, Ting Cao, Wei Liu, Weisheng Liu, Wenwu Qin*, and Huichen Guo*.Fast and Selective Two-Stage Ratiometric Fluorescent Probes for Imaging of Glutathione in Living Cells.Anal. Chem. 2017, 89, 13112-13119.*通讯作者

Ma Y#, Wang H#, Yan D, Wei Y, Cao Y, Yi P, Zhang H, Deng Z, Dai J, Liu X, Luo J, Zhang Z*, Sun S*, and Guo H*.Magnetic Resonance Imaging Revealed Splenic Targeting of Canine Parvovirus Capsid Protein VP2.Scientific Reports, 2016, 6: 23392.*通讯作者

Han SC#, Guo HC#, Sun SQ*, Jin Y, Wei YQ, Feng X, Yao XP, Cao SZ, Liu DX, Liu XT. Productive Entry of Foot-and-Mouth Disease Virus via Macropinocytosis Independent of Phosphatidylinositol 3-Kinase. Scientific Reports, 2016, 6: 19294.第一作者

Wang X, Wang D, Guo Y, Yang C, Liu X, Iqbal A, Liu W, Qin W*, Yan D, and Guo H*.Fluorescent glutathione probe based on MnO2-phenol formaldehyde resin nanocomposite.Biosensors & Bioelectronics, 2016, 77: 299-305.*通讯作者

Gong DY#, Tian YJ, Yang CD, Iqbal A, Wang ZP, Liu WS, Qin WW*, Zhu XT, Guo HC*. Afluorescence enhancement probe based on BODIPY for the discrimination of cysteine from homocysteine and glutathione. Biosensors and Bioelectronics, 2016, 85: 178-183.*通讯作者

Gao Y, Sun S, Guo H*.Biological function of Foot-and-mouth disease virus non-structural proteins and non-coding elements.Virol J, 2016, 13: 107.*通讯作者

Xu J#, Guo HC#, Wei YQ, Shu L, Wang J, Li JS, Cao SZ*, Sun SQ*. Phylogenetic Analysis of Canine Parvovirus Isolates from Sichuan and Gansu Provinces of China in 2011, Transboundary and Emerging Diseases, 2015, 62(1): 91-95.第一作者

Ao D#, Guo HC#, Sun SQ*, Sun DH, Fung TS, Wei YQ, Han SC, Yao XP, Cao SZ, Liu DX, Liu XT. Viroporin Activity of the Foot-and-Mouth Disease Virus Non-Structural 2B Protein. PLoS One, 2015, 10(5): e125828.第一作者

Wang XD#, Wang D, Guo YL, Yang CD, Iqbal A, Liu WS, Qin WW*, Yan D, Guo HC*. Imidazole derivative-functionalized carbon dots: using as a fluorescent probe for detecting water and imaging of live cells, Dalton Transactions, 2015, 44(12): 5547-5554. *通讯作者

Han SC#, Guo HC#, Sun SQ*, Shu L, Wei YQ, Sun DH, Cao SZ, Peng GN, Liu XT. Full-length genomic characterizations of two canine parvoviruses prevalent in Northwest China,Archives of Microbiology, 2015, 197(4): 621-626.第一作者

Guo HC#, Jin Y#, Zhi XY, Yan D, Sun SQ*. NLRP3 Inflammasome Activation by Viroporins ofAnimal Viruses, Viruses, 2015, 7(7): 3380-3391.第一作者 

Guo HC#, Jin Y, Han SC, Sun SQ*, Wei YQ, Liu XJ, Feng X, Liu DX, Liu XT. Quantitative Proteomic Analysis of BHK-21 Cells Infected with Foot-and-Mouth Disease Virus SerotypeAsia 1. PLoS One, 2015, 10(7): e132384.第一作者 

Guo HC#, Yan D, Wei YQ, Han SC, Qian HS, Yang YS, Zhang YP, Liu XT, Sun SQ*. Inhibition of Murine Bladder Cancer Cell Growth In Vitro by Photocontrollable siRNA Based on Upconversion Fluorescent Nanoparticles. PLoS One, 2014, 9(11): e112713. 第一作者

Tong GX#*, Liu FT, Wu WH, Tong CL, Qiao R, Guo HC*. Facile bubble-assisted evaporation-induced assembly of high-density arrays of Co3O4 nano/microlotus leaves: fluorescent properties, drug delivery, and biocompatibility. Crystengcomm, 2014, 16(2014): 1645-1651.*通讯作者

Guo HC#, Sun SQ*, Sun DH, Wei YQ, Xu J, Huang M, Liu XT, Liu ZX, Luo JX, Yin H, Liu DX*. Viroporin activity and membrane topology of classic swine fever virus p7 protein. The International Journal of Biochemistry & Cell Biology, 2013, 45(7): 1186-1194.第一作者

Guo HC#, Sun SQ*, Jin Y, Yang SL, Wei YQ, Sun DH, Yin SH, Ma JW, Liu ZX, Guo JH, Luo JX, Yin H, Liu XT*, Liu DX*. Foot-and-mouth disease virus-like particles produced by a SUMO fusion protein system in Escherichia coli induce potent protective immune responses in guinea pigs, swine and cattle. Veterinary Research, 2013, 44(1): 48.第一作者 

Guo HC#, Hao RZ, Qian HS, Sun SQ*, Sun DH, Yin H, Liu ZX, Liu XT*. Upconversion nanoparticles modified with aminosilanes as carriers of DNAvaccine for foot-and-mouth disease, Appl Microbiol Biotechnol, 2012, 95(5): 1253-1263.第一作者

Liu XH#, Qian HS*, Ji YP, Li ZQ, Shao Y, Hu Y, Tong GX, Li LC, Guo WD*, Guo HC*. Mesoporous silica-coated NaYF4 nanocrystals: Facile synthesis, in vitro bioimaging and photodynamic therapy of cancer cells. RSC Advances, 2012, 2: 12263-12268.*通讯作者 

Guo HC#, Qian HS, Sun SQ*, Sun DH, Yin H, Cai XP, Liu ZX, Wu JY, Jiang T, Liu XT*. Hollow mesoporous silica nanoparticles for intracellular delivery of fluorescent dye. Chemistry Central Journal, 2011, 5(1): 1. 第一作者

Qian HS#, Zhu EB, Zheng SJ, Li ZQ, Hu Y, Guo CF, Yang XY, Li LC, Tong GX, Guo HC*. One-pot synthesis of biocompatible Te@phenol formaldehyde resin core-shell nanowires with uniform size and unique fluorescent properties by a synergized soft-hard template process. Nanotechnology, 2010, 21(49): 495602.*通讯作者

Guo HC#, Sun SQ, Ma JT, Liu ZX*, Liu XT, QG XIE, ABicistronic DNAVaccine Containing Gene of FMDV and Bovine IFN-α Can Prime Humoral and Cellular Immune Responses of Guinea Pigs. Turk. J. Vet. Anim. Sci. 2008, 32(2): 85-91.第一作者 

Guo HC#*, Liu X, Liu Z, Yin H, Ma J, Wang Y, Shang Y, Zhang Q, Li D, Guo J, Lu Z, Xie Q. Recent Outbreaks of Foot-and-Mouth Disease Type Asia 1 in China. J Vet Med B, 2006, 53: 29-33.*第一作者

Guo HC#, Liu ZX, Sun SQ, Bao HF, Chen YL, Liu XT, Xie QG*. Immune response inguinea pigs vaccinated with DNAvaccine of foot-and-mouth disease virus O/China99. Vaccine, 2005, 23: 3236-3242. 第一作者

Guo HC#, Liu ZX*, Sun SQ, Leng QW, Li D, Liu XT, Xie QG*. The effect of bovine IFN-α on the immune response in guinea pigs vaccinated with DNAvaccine of foot-and-mouth disease virus. Acta Biochim Biophys Sinica, 2004, 36(10): 701-706.第一作者

 张智慧,魏衍全,谷玲军,张韵,孙世琪,尹双辉,郭慧琛*.携带高滴度猪瘟病毒C株猪睾丸细胞株的建立及蛋白质组学分析.病毒学报.2021,37(03):648-657.*通讯作者

李璐莹,董虎,卢渊录,王苗苗,孙世琪,郭慧琛*.口蹄疫病毒氨基酸改造对其病毒样颗粒稳定性的影响.生物工程学报.2021,37(07).*通讯作者

韩世充#, 毛乐娇, 孙世琪, 张智慧, 莫亚霞, 柳海云, 智晓莹, 郭慧琛*. Sec62在FMDV诱导的内质网应激和抗病毒免疫中的作用研究. 中国兽医科学, 2019, S1(49): 307-312.*通讯作者

茹嘉喜#, 滕志东, 董虎, 孙世琪, 郭慧琛*. 树枝状介孔硅纳米微球作为口蹄疫病毒样颗粒疫苗佐剂的研究. 中国兽医科学, 2019, S1(49): 350-353. *通讯作者

侯风萍#, 孙世琪, 郭慧琛*. 基于病毒样颗粒的免疫层析技术用于O型口蹄疫病毒抗体的快速定量检测. 中国兽医科学, 2019, S1(49): 215-217.*通讯作者

张韵#, 白满元, 王蕊, 孙世琪, 智晓莹, 郭慧琛*. A型口蹄疫病毒样颗粒抗体金标诊断方法的建立. 中国兽医科学, 2019, S1(49): 218-221. *通讯作者

张禹#, 张韵, 孙世琪, 马小军, 张小丽*, 郭慧琛*. 猪圆环病毒2型抗体胶体金免疫层析检测方法的建立. 中国预防兽医学报, 2019, 41(07): 705-709.*通讯作者 

罗新#, 孙世琪, 滕志东, 白满元, 穆素雨, 郭慧琛*, 蔺国珍*. Poly(I∶C)增强口蹄疫病毒样颗粒疫苗免疫效果的研究. 中国兽医科学, 2019, 49(05): 632-638.*通讯作者

白满元#, 柳海云, 张韵, 孙世琪, 郭慧琛*. 益于猪圆环病毒2型增殖的PK-15细胞系的克隆筛选与应用. 中国兽医科学, 2018, 48(12): 1489-1496.*通讯作者 

郭笑然#, 韩世充, 张小丽, 孙世琪, 马小军, 郭慧琛*. A型塞尼卡病毒的分离鉴定及生物学特性研究.病毒学报, 2018, 34(05): 555-563.*通讯作者 

李淑萍#, 孙世琪, 莫亚霞, 胡永浩*, 郭慧琛*. O型口蹄疫病毒样颗粒编码基因的真核表达载体构建及表达. 动物医学进展, 2019, 40(01): 1-6.*通讯作者

宋品#, 孙世琪, 董虎, 滕志东, 曹随忠, 郭慧琛*, 余树民*. 猪细小病毒病毒样颗粒的体外组装. 中国兽医科学, 2017, 47(06): 707-712.*通讯作者

杨云裳#, 张彬, 张应鹏, 林森森, 赵旭东, 孙世琪, 郭慧琛*. 芹菜素与犬细小病毒衣壳蛋白相互作用研究. 中兽医医药杂志, 2014, 33(02): 5-11.*通讯作者 

敖大#, 孙世琪, 董虎, 徐进, 孙德惠, 魏衍全, 王海明, 郭慧琛*, 曹随忠*. 口蹄疫病毒2B蛋白基因的原核表达及其表达产物的细胞毒性分析. 中国兽医科学, 2014, 44(02):140-145.*通讯作者 

魏衍全#, 孙世琪, 孙德惠, 郭慧琛*. 串联亲和纯化中应用不同标签组合的研究进展.中国兽医科学, 2012, 42(09): 987-990.*通讯作者 

徐进#, 孙世琪, 曹随忠*, 孙德惠, 郭慧琛*. 犬细小病毒病基因工程疫苗的研究进展. 中国兽医科学, 2012, 42(05): 541-544.*通讯作者

郭慧琛#, 刘在新*, 孙世琪, 冷青文, 刘湘涛, 谢庆阁*. 口蹄疫病毒多基因重组质粒的体外表达及衣壳组装. 病毒学报, 2005, 21(03): 228-234.第一作者 

郭慧琛#, 孙世琪, 刘在新*. 佐剂及其在基因免疫研究中的应用. 中国兽医科技, 2005, 35(04): 315-321.第一作者

郭慧琛#, 孙世琪, 刘在新, 谢庆阁. 免疫增强重组流感病毒体.中国预防兽医学报, 2004,26(05): 76-79.第一作者

郭慧琛#, 孙世琪, 云涛, 张腾国, 包慧芳, 陈应理, 马军武, 刘湘涛, 刘在新, 谢庆阁.口蹄疫病毒3D蛋白对DNA疫苗免疫效果的影响. 中国兽医科技, 2004, 34(03):12-17.第一作者

专著：

《口蹄疫》，著作，中国农业出版社出版，参编；

《牛传染性疾病早防快治》，著作，中国农业科学技术出版社，参编；

《动物疫苗学著作》，著作，中国农业科技出版社，参编；

《兽医默克手册（第十版）》，著作，中国农业出版社，参编；

《天然分子免疫学》，著作，科学出版社，副主编；

《动物病毒样颗粒技术》，著作，中国科学出版社，主编。

专利：

2022.03“一种检测A型塞内卡病毒的荧光定量PCR引物及试剂盒”专利号“ZL201910013717.2”第一完成人

2022.04“一种耐热型口蹄疫重组病毒株、由该病毒株制成的灭活疫苗及其应用”专利号“ZL202010725839.7”第一完成人

2022.09“一种具有多级孔结构的二氧化硅材料制备方法”专利号“ZL201911078617.4”第一完成人

2022.10“一种耐热型口蹄疫重组病毒株及其在制备口蹄疫灭活疫苗中的应用”专利号“ZL202010724770.6”第一完成人

2022.11“一种开口型空心硅纳米胶囊及其制备方法和用途”专利号“ZL202111367318.X”第一完成人

2021.06“用于O型口蹄疫病毒抗体定量检测的上转换发光免疫层”专利号“ZL202010061291.0”第一完成人

2021.07“一种口蹄疫病毒样颗粒体外组装的方法及应用”专利号“ZL202010116531.2”第一完成人

2021.08“核糖体蛋白RPL13抑制剂在制备抑制IRES-依赖性翻译的病毒复制的药物中的应用”专利号“ZL201910610793.1”第一完成人

2021.08“一种基于病毒样颗粒的C型口蹄疫病毒抗体竞争ELISA检测试剂盒”专利号“ZL201811492145.2”第三完成人

2020.01“MINERALIZED FOOT-AND-MOUTH DISEASE VIRUS LIKE PARTICLES, ANDPREPARATION METHOD AND USE THEREOF”专利号“US 10532092B2”第一完成人（国际专利）

2020.01“VIRUS-LIKE PARTICLE OF SENECAVIRUS A”专利号“US 10532077B2”第一完成人（国际专利）

2020.11“METHOD FOR PREPARING FOOT-AND-MOUTH DISEASE VIRUS-LIKE PARTICLES, AND TEST STRIP FOR DETECTING FOOT-AND-MOUTH DISEASE”专利号“US10829741B2”第二完成人（国际专利）

2020.07“口蹄疫病毒样颗粒在作为重组质粒运载载体中的应用”专利号“ZL201610929291.1”第一完成人

2020.10“矿化口蹄疫病毒样颗粒及其制备方法和应用”专利号“ZL201710539048.3”第一完成人

2020.11“金纳米颗粒作为佐剂在制备病毒样颗粒疫苗中的应用”专利号“ZL201710553111.9”第一完成人

2019.12“一种A型赛内卡病毒病毒样颗粒及其制备方法和用途”专利号“ZL201810483236.3”第一完成人

2019.07“一种0型口蹄疫病毒样颗粒及其制备方法和用途”专利号“ZL201610929279.0”第二完成人

2018.07“一种肿瘤药物靶向载体及制备方法与应用”专利号“ZL201510128809.7”第二完成人

2017.08“一种用病毒样颗粒包被量子点的方法”专利号“ZL-201510037803.9”第二完成人

2017.09“猪圆环病毒2型抗体快速检测层析试纸条及制备方法”专利号“ZL201610190933.0”第三完成人

2016.01“嵌合IBV4/91株纤突蛋白膜外区基因片段的重组传染性支气管炎病毒及其构建方法和应用”专利号“ZL201310573277.9”第一完成人

疫苗新兽药证书(2项)

（1）猪口蹄疫 O 型病毒样颗粒疫苗，一类新兽药，证号:(2021)新兽药证字57号（第二）

（2）牛口蹄疫 O 型病毒样颗粒疫苗.，一类新兽药，证号:(2021)新兽药证字58号（第一）

先后获得中国专利优秀奖（第2，2022）、中国农业科学院科技成果奖（杰出科技创新奖，第1,2022）、甘肃省专利发明人奖（第1，2021）、甘肃省专利一等奖（第2,2020）、中国农业科学院成果转化奖（第2,2020）、第九届大北农科技奖（第2，2015）等奖项6项。