研究方向：人畜共患病及兽医公共卫生学

承担项目/课题：

（1）主持国家自然科学基金青年科学基金：旋毛虫诱导分化的巨噬细胞调节弓形虫再感染的分子机制（31602045，2017/01-2019/12），18万元；

（2）主持甘肃省自然科学基金：旋毛虫硫氧还蛋白过氧化物酶调节宿主Th2型免疫应答的研究（1606RJZA349，2016/09-2018/08），3万元。

（3）主持中国农业科学院兰州兽医研究所基本科研业务费：基于组学分析筛选旋毛虫包囊形成参与基因（1610312020012，2020.01-2020.12），10万元：

文章发表：

[1] Qi-Wang Jin, Nian-Zhang Zhang, Wen-hui Li, et al. Trichinella spiralis Thioredoxin peroxidases 2 regulates protective Th2 immune response in mice by directly inducing M2 macrophages. Front. Immunol. （接收）

[2] Cai Y, Zhang NZ, Gong QL, Zhao Q, Zhang XX. Prevalence of Cryptosporidium in dairy cattle in China during 2008–2018: A systematic review and meta-analysis. Microb. Pathogenes. 2019, 132: 193-200.

[3] Wang JL, Zhang NZ, Li TT, He JJ, Elsheikha HM, Zhu XQ. Advances in the development of anti-Toxoplasma gondii vaccines: challenges, opportunities, and perspectives. Trends Parasitol. 2019, 35(3):239-253.

[4] Zhang N, Li W, Fu B. Vaccines against Trichinella spiralis: Progress, challenges and future prospects. Transbound. Emerg. Dis. 2018, 65:1447-1458.

[5] Zhang NZ, Gao Q, Wang M, Hou JL, Zhang FK, Hu LY, Zhu XQ. Protective efficacy against acute and chronic Toxoplasma gondii infection induced by immunization with the DNA vaccine TgDOC2C. Front. Microbiol. 2018, 9:2965.

[6] Zhang NZ, Gao Q, Wang M, Elsheikha HM, Wang B, Wang JL, Zhang FK, Hu LY, Zhu XQ. Immunization with a DNA vaccine cocktail encoding TgPF, TgROP16, TgROP18, TgMIC6, and TgCDPK3 genes protects mice against chronic toxoplasmosis. Front. Immunol. 2018, 9:1505.

[7] Gao Q, Zhang NZ, Zhang FK, Wang M, Hu LY, Zhu XQ. Immune response and protective effect against chronic Toxoplasma gondii infection induced by vaccination with a DNA vaccine encoding profilin. BMC Infect. Dis. 2018, 18:117.

[8] Wang X, Zhang NZ, Ma CF, Zhang XX, Zhao Q, Ni HB. Epidemiological investigation and genotype of Chlamydia exposure in pigeons in three provinces in Northern China. Vector Borne Zoonotic Dis. 2018, 18:181-184.

[9] Hu LY, Zhang NZ, Zhang FK, Wang M, Gao Q, Wang JL, Zhu XQ. Protective immunity induced by a DNA vaccine expressing GRA16 of Toxoplasma gondii against toxoplasmosis in mice. Biomed Res. Int. 2017, 1295038.

[10] Wang M, Yang XY, Zhang NZ, Zhang DL, Zhu XQ. Evaluation of protective immune responses induced by recombinant TrxLp and ENO2 proteins against Toxoplasma gondii infection in BALB/c mice. Biomed Res. Int. 2016, 3571962.

[11] Zhang NZ, Liu JY, Li WH, Li L, Qu ZG, Li TT, Cui JM, Yang Y, Jia WZ, Fu BQ. Cloning and characterization of thioredoxin peroxidases from Trichinella spiralis. Vet. Parasitol. 2016, 231: 53-58.

[12] Zhang NZ, Xu Y, Wang M, Petersen E, Chen J, Huang SY, Zhu XQ. Protective efficacy of two novel DNA vaccines expressing Toxoplasma gondii rhomboid 4 and rhomboid 5 proteins against acute and chronic toxoplasmosis in mice. Expert Rev. Vaccines. 2015, 14: 1289-1297.

[13] Zhang NZ, Wang M, Xu Y, Petersen E, Zhu XQ. Recent advances in developing vaccines against Toxoplasma gondii: an update. Expert Rev. Vaccines. 2015, 14: 1609-1621.

授权发明专利（第1或第2发明人）

[1] 张念章，付宝权，李文卉，盖文燕. 一种多肽抗原检测猪旋毛虫抗体的试剂盒及其检测方法，ZL201711297851.7.

[2]李文卉，张念章，闫鸿斌，李立，岳龙，付宝权. 一种用于诊断羊多头蚴病的重组蛋白，ZL201510405279.6.

[3]逯忠新，贺英，储岳峰，赵萍，高鹏程，张念章. 一种山羊传染性胸膜肺炎的快速检测试剂盒及其制备方法，ZL201110248562.4