学习经历

2003.9—2007.06  河北北方学院，动物科技学院，学士

2007.9—2010.06  华中农业大学，农业微生物学国家重点实验室，硕士

2011.01—2014.11 德国慕尼黑大学，病理学研究所，博士（Dr.rer.nat）

工作经历

2015.01—2021.01  Cancer Research UK Manchester Institute，博士后

2021.05—至今  兰州大学公共卫生学院，教授

2022.01—至今  科学技术发展研究院 副院长（挂职）。

目前承担课程

主要科研成果

研究方向：

通过转录组学测序和生物信息学手段相结合的方法，挖掘和鉴定与癌症发生发展与转移相关的非编码RNA

利用分子生物学、细胞生物学和动物模型等手段，研究lncRNA在癌症重要细胞信号通路中的分子机理

RNA结合蛋白的转录调控机制

主持或参与科研项目：

1.英国癌症研究院重点研究支持经费，13.5万英镑/年，第一参与人

2.英国卓越肺癌研究中心研究经费，2万英镑/年，第一参与人

3. 中央高校科研启动经费，主持

发表主要论文或专著:

1.Lei Shi, Peter Magee, Matteo Fassan, Sudhakar Sahoo, Hui Sun Leong, Dave Lee, Robert Sellers, Laura Brulle-Sumare, Stefano Cairo, Tiziana Monteverde, Stefano Volinia, Duncan Smith, Gianpiero Di Leva, Francesca Galuppini, Athanasios Paliouras, Kang Zeng, Raymond O'Keefe, and Michela Garofalo. A KRAS-responsive long non-coding RNA KIMAT1 controls microRNA processing. Nature Communications. (2021) 12:2038.doi.org/10.1038/s41467-021-22337. (IF,12.12, JCR Q1).

2. Lucy Ginn, Manuela La Montagna, Qinghua Wu, Lei Shi#. Discovery the functions of long non-coding RNA in viral diseases. Reviews in Medical Virology. November 27 2020.DOI:10.1002/RMV.2198 (通讯作者, IF 4.221, JCR Q2).

3. Athanasios R. Paliouras*, Marta Buzzetti* Lei Shi*, Ian J. Donaldson, Peter Magee, Sudhakar Sahoo, Hui-Sun Leong, Matteo Fassan, Matthew Carter, Gianpiero Di Leva, Matthew Krebs, Fiona Blackhall, Christine M. Lovly and Michela Garofalo. Vulnerability of drug-resistance EML4-ALK rearranged lung cancer to transcriptional inhibition. EMBO Molecular Medicine. 2020 Jun 17; e110099. Doi: 10.15252/emmm.201911099 (并列第一作者,IF 10.293, JCR Q1).

4. Lei Shi, Justin Middleton, Young-Jun Jeon, Peter Magee, Dario Veneziano, Alessandro Lagana, Hui-Sun Leong, Sudhakar Sahoo, Matteo Fassan, Richard Booton, Rajesh Shan, Philip A.J. Crosbie and Michela Garofalo. KRAS induces lung tumorigenesis through microRNAs modulation. Cell Death & Disease. 2018 Feb 13; 9(2):219 (IF 6.3, JCR Q1).

5. Lei Shi, Rene Jackstadt, Helge Siemens, Huihui Li, Thomas Kirchner, Heiko Hermeking. p53-induced miR-15a/16-1 and AP4 form a double-negative feedback loop to regulate epithelial-mesenchymal transition and metastasis in colorectal cancer. Cancer Research. 2014 Jan 15; 74(2): 532-42 (IF 9.7, JCR Q1).

6. Srivatsava Naidu*, Lei Shi*, Peter Magee, Justin D. Middleton, Alessandro Lagana, Sudhakar Sahoo, HuiSun Leong, Melanie Galvin, Kristopher Frese, Caroline Dive, Vincenza Guzzardo, Metteo Fassan, Michela Garofalo, PDGFR-modulated miR-23b cluster and miR-125a-5p suppress lung tumorigenesis by targeting multiple components of KRAS and NF-kB pathways.Scientific Reports. 2017 Nov 13;7 (1):15441.

7. Peter Magee*, Lei Shi*, Michela Garofalo, Role of microRNAs in chemoresistance. Annals of Translational Medicine, 2015; 3(21): 332.

8. Lucy Ginn, Lei Shi, Manuela La Montagna and Michela Garofalo. LncRNAs in Non-Small-Cell Lung Cancer. Non-coding RNA 2020, 6, 25; doi:10.3390/ncrna6030025.

9. Srivatsava Naidu, Lei Shi, Michela Garofalo. MicroRNAs in lung tumorigenesis and chemoresistance, American Association Cancer Research Education Book, 2015: 71-74. doi: 10.1158/AACR.EDB-15-7984.

10.英国专利：lncRNA ASOs for KRAS Amplified Tumors, 实验完成人，排名第二。

社会兼职和社会服务

Non-coding RNA Journal Reviewers Board(编委)

审稿人：Cancers(IF=6.3)、Journal of Immunology Research、Cancer Gene Therapy、Oncology Letters、Journal of Cancer和Biomolecules

中国毒理学会会员，中国细胞生物学学会会员，中国生物化学与分子生物学学会会员，美国癌症协会会员，欧洲癌症协会会员

E-mail  ；leishi@lzu.edu.cn