主要从事多肽及抗体药物研发，参与2个候选多肽药物的临床前研究（1.1类新药，目前正在临床Ⅰ、Ⅱ期），在Acta Pharm Sin B.、J Med Chem.、Phytomedicine.等高水平期刊发表论著多篇，曾获欧洲克罗恩病和结肠炎组织（ECCO）最佳摘要、美国消化疾病周（DDW）Oral Pre。

1. Shi Z, Liu X, Wu S, Song N, Tang Q, Li H, Luo S, Chan A, Cai X, Liu H*, Jiang X*. Discovery of Novel Peptide Antagonists Targeting GPR55 for Liver Inflammation and Fibrosis. J Med Chem. 2024 Jul 25;67(14):12085-12098. doi: 10.1021/acs.jmedchem.4c00834.（中科院1区，IF=7.3，共同通讯）
2. Liu H¹, Hong Y¹, Chen H¹, Wang X, Dong J, Li X, Shi Z, Wang J, Zhou L, Zeng Q, Tang Q, Liu Q, Rieder F, Chen B, Chen M, Zhang Y, Mao R, Jiang X*. Dual Activation of GCGR/GLP1R Signaling Ameliorates Intestinal Fibrosis via Metabolic Regulation of Histone H3K9 Lactylation in Epithelial Cells. Acta Pharm Sin B. 2024. （中科院1区，IF=14.5，一作）
3. Liu H¹, Hong Y, Wang X, Dong J, Li X, Shi Z, Wang J, Zhou L, Rieder F, Chen B, Chen M, Zhang Y, Mao R, Jiang X*. 173 Dual Activation of GCGR/GLP1R Signaling Ameliorates Intestinal Fibrosis via Metabolic Regulation of Histone H3K9 Lactylation in Epithelial Cells. Gastroenterology. Volume 166, Issue 5, Supplement, 18-21 May 2024, Pages S-39-S-40doi.org/10.1016/S0016-5085(24)00583-3.（会议摘要）
4. Liu H¹, Hong Y, Wang X, Dong J, Li X, Shi Z, Wang J, Zhou L, Rieder F, Chen B, Chen M, Zhang Y, Mao R, Jiang X*. OP25 Dual Activation of GCGR/GLP1R Signaling Ameliorates Intestinal Fibrosis via Metabolic Regulation of Histone H3K9 Lactylation in Epithelial Cells. J Crohns Colitis. Volume 18, Issue Supplement_1, January 2024, Pages i44-i46, 10.1093/ecco-jcc/jjad212.0025.（会议摘要）
5. Zhao Q¹, Dong J¹, Liu H¹, Chen H, Yu H, Ye S, Yu S, Li Y, Qiu L, Song N, Xu H, Liu Q, Luo Z, Li Y, Wang R, Chen G, Jiang X*. Design and Discovery of a Highly Potent Ultralong-acting GLP-1 and Glucagon Co-agonist for Attenuating Renal Fibrosis. Acta Pharm Sin B. 2024 Mar;14(3):1283-1301. doi: 10.1016/j.apsb.2023.11.020. （中科院1区，IF=14.5，共一）
6. Liu H, Lu Z, Lin B, Zhan JY, Gui S, Chen W, Tang P, Li P, Yang W, Lin B*. Inferior Vena Cava Stenosis-induced Deep Vein Thrombosis is Influenced by Multiple Factors in Rats. Biomed Pharmacother. 2020 Aug;128:110270. doi: 10.1016/j.biopha.2020.110270.（中科院1区，IF=7.5，一作）
7. Liu H, Li P, Lin J, Chen W, Guo H, Lin J, Liu J, Lu Z, Yao X, Chen Y, Lin B*. Danhong Huayu Koufuye Prevents Venous Thrombosis through Antiinflammation via Sirtuin 1/NF-κB Signaling Pathway. J Ethnopharmacol. 2019 Sep 15;241:111975. doi: 10.1016/j.jep.2019.111975.（中科院1区，IF=5.4，一作）
8. Tang P¹, Liu H¹*, Lin B, Yang W, Chen W, Lu Z, Li P, Gui S, Zhan Y, Lin B*. Spatholobi Caulis Dispensing Granule Reduces Deep Vein Thrombus Burden through Antiinflammation via SIRT1 and Nrf2. Phytomedicine. 2020 Oct;77:153285. doi: 10.1016/j.phymed.2020.153285.（中科院1区，IF=7.9，共一及共通讯）
9. Yao X¹, Liu H¹, Li P, Chen W, Guan S, Chen Y, Wu Y, Lin B*. Aqueous Extract of Whitmania Pigra Whitman Alleviates Thrombus Burden via Sirtuin 1/NF-κB Pathway. J Surg Res. 2020 Jan;245:441-452. doi: 10.1016/j.jss.2019.07.094.（中科院3区，IF=2.2，共一）
10. Wang Y, Xue F, Cheng W, Zhao Q, Song N, Shi Z, Liu H, Li Y, Tang Q, Liu Q, Wang Y, Zhang F, Jiang X*. Design and Synthesis of Novel Ultralong-acting Peptides as EDP-EBP Interaction Inhibitors for Pulmonary Fibrosis Treatment. J Med Chem. 2024 Apr 25;67(8):6624-6637. doi: 10.1021/acs.jmedchem.4c00067.（中科院1区，IF=7.3）
11. Dong J, Xiao J, Li J, Yu H, Zhao Q, Tang Q, Chen H, Liu H, Wu K, Lei J, Wang R, Jiang X*. Discovery and Design of Novel Cyclic Peptides as Specific Inhibitors Targeting CCN2 and Disrupting CCN2/EGFR Interaction for Kidney Fibrosis Treatment. J Med Chem. 2023 Jun 22;66(12):8251-8266. doi: 10.1021/acs.jmedchem.3c00594.（中科院1区，IF=7.3）
12. Yao X, Chen W, Liu J, Liu H, Zhan JY, Guan S, Lu Z, Tang P, Li P, Lin B. Deep Vein Thrombosis is Modulated by Inflammation Regulated via Sirtuin 1/NF-κB Signalling Pathway in a Rat Model. Thromb Haemost. 2019 Mar;119(3):421-430. doi: 10.1055/s-0038-1676987. （中科院2区，IF=6.7）

13. 一种多肽化合物及其在骨关节炎中的应用。申请号：2024103409292. 蒋先兴, 洪玉洁, 刘涵。