基础研究：布鲁氏菌与宿主相互作用

以布鲁氏菌为主要病原模型，围绕重要家畜病原与宿主相互作用这一核心，研究病原对宿主细胞的免疫调节机制和死亡调节机制。

应用研究：布鲁氏菌mRNA疫苗和亚单位疫苗等新型疫苗研制

在研项目：

甘肃省自然科学基金重点项目  主持人 （经费20万，2025-2028）

国家重点研发计划  骨干 （经费100万，2024-2029）

甘肃省科技创新人才计划  骨干 （经费80万，2024-2027）

1. Meng-Yao Sun #; Li-Bo Cao #; Qin-Ling Wan; Zhen-Zhen Li; Jun-Zheng Du; Hong-Bing Shu; Yu-Lin Yang; Lumpy skin disease virus protein LSDV122 impairs IFN-I receptor complex formation to evade host innate immunity, PLoS Pathogens, 2026, 22(1) (共同第一作者)

2. Yu-Lin Yang; Huai-Jie Jia; Meng-Yao Sun; Ai-Min Guo; Tian Xia; Hong-Bing Shu; Li-Bo Cao; Lumpy skin disease virus LSDV001 protein positively regulates inflammatory response by promoting assembly of the TAK1-TAB2/3 complex, mBio, 2025, 16(10)

3. Zhen-Zhen Li; Yu-Lin Yang; Meng-Yao Sun; Hong-Bing Shu; Li-Bo Cao; Lumpy skin disease virus LSDV087 positively regulates innate immune response by promoting oligomerization of MITA/STING, Journal of Virology, 2025, 99(11), 2026, 22(1)

4. Li-Bo Cao; Zi-Lun Ruan; Yu-Lin Yang; Nian-Chao Zhang; Chuan Gao; Cheguo Cai; Jing Zhang; Ming-Ming Hu; Hong-Bing Shu; Estrogen receptor α-mediated signaling inhibits type I interferon response to promote breast cancer, Journal of Molecular Cell Biology, 2023, 15(7)

5. Yu-Lin Yang #; Li-Bo Cao #; Wen-Rui He; Li Zhong; Yi Guo; Qing Yang; Hong-Bing Shu; Ming-Ming Hu; Endocytosis triggers V-ATPase-SYK–mediated priming of cGAS activation and innate immune response, Proceedings of the National Academy of Sciences, 2022, 119(43) (共同第一作者)

6. Wen-Rui He; Li-Bo Cao; Yu-Lin Yang; Duo Hua; Ming-Ming Hu; Hong-Bing Shu; VRK2 is involved in the innate antiviral response by promoting mitostress-induced mtDNA release, Cell Mol Immunol 2021, 18, 1186-1196.

7. Ming-Ming Hu; Wen-Rui He; Peng Gao; Qing Yang; Ke He; Li-Bo Cao; Shu Li; Yu-Qi Feng; Hong-Bing Shu; Virus-induced accumulation of intracellular bile acids activates the TGR5-β-arrestin-SRC axis to enable innate antiviral immunity, Cell Res 2019, 29, 193-205.