Dr. Xin Wu is a Professor and Ph.D. Supervisor at the Lanzhou University and Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences. She received her Ph.D. from Wuhan University in 2019. From 2020 to 2023, she conducted postdoctoral research at the University of Southern California and the Cleveland Clinic.
Dr. Wu’s research focuses on the pathogenic mechanisms of pathogens-induced sepsis. Her work integrates clinical investigation with fundamental research, employing high-throughput approaches such as single-cell sequencing and proteomics to analyze clinical samples. Using molecular and cellular biology techniques, she aims to elucidate host–pathogen interactions and develop novel vaccines and therapeutic strategies.
She has published multiple SCI-indexed papers, including several as first or corresponding author in leading international journals such as Nature Communications, mBio, and Cell Insight. She currently serves as Principal Investigator for multiple research projects, including the National Natural Science Foundation of China (General Program), the National Overseas High-Level Talent Program, and major projects supported by the Gansu Provincial Joint Fund.
Education
Professional Experience
Research Interests
Research Funding
Gansu Provincial Science & Technology Program (Subproject), PI (2024–2027)
1.Wu, X.; Lei, C.-Q.; Xia, T.; Zhong, X.; Yang, Q.; Shu, H.-B.
Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination.
Nature Communications, 2019, 10: 4115.
2.Wu, X.; Xia, T.; Shin, W.-J.; et al.
Viral mimicry of interleukin-17A by SARS-CoV-2 ORF8.
mBio, 2022, 13(2).
3.Yang, J.; Wang, Y.; Hou, Y.; Xia, T.; Wu, X.*
Evasion of host defense by Brucella.
Cell Insight, 2024, 3(1).
4.Hou, Y.-P.; Yang, J.-K.; Wang, Y.; Wu, X.*
African Swine Fever Virus MGF_110-8L promotes host cell autophagy and suppresses interferon signaling by activating the unfolded protein response.
Veterinary Microbiology, 2026.
5.Yang, J.-K.; Huang, S.; Hou, Y.-P.; Wu, X.*
Brucella Omp25 activates the unfolded protein response to promote intracellular proliferation and inflammation.
Journal of Biological Chemistry, 2026.
6.Lei, C.-Q.; Wu, X.; Zhong, X.; Jiang, L.; Zhong, B.; Shu, H.-B.
USP19 inhibits TNF-α– and IL-1β–triggered NF-κB activation by deubiquitinating TAK1.
The Journal of Immunology, 2019, 203(1): 259–268.
7.Xia, T.; Wu, X.; et al.
Glucosylceramide is essential for Heartland and Dabie bandavirus glycoprotein-induced membrane fusion.
PLOS Pathogens, 2023, 19(3).
