Research Areas: Preventive Veterinary Science, especially in the Animal Vaccines and Molecular Immunology / Molecular Biology of Animal Virus

HONORS AND AWARDS:

She has been awarded 1 2nd prize of Gansu Provincial Scientific and Technological Progress Award, 1 1st prize of the China Agricultural Science and Technology Award, and 1 2nd prize of Gansu Provincial Patent Award. Research achievements have obtained 2 Class II New Veterinary Drug Certificates and 1 Class III New Veterinary Drug Certificate; authorized 6 National Invention Patents.

1.Ruiming Yu, Liping Zhang, Dongsheng Wang, Jun Yang, Peng Zhou, Yuhan Wen, Mingxia Li, Yingjie Bai, Zhongwang Zhang, Yousheng Peng, Yanzhen Lu, Dan Li, Jian He, Yonglu Wang, Huichen Guo, Li Pan*, Xinsheng Liu*. Characterization of a cell-adapted completely attenuated genotype GIIa porcine epidemic diarrhea virus strain. Virology 604 (2025)110407.

2.Yingjie Bai, Ruiming Yu, Guangqing Zhou, Liping Zhang, TianTian Wang, Ya Liu, Dongsheng Wang, Zhongwang Zhang, Yonglu Wang, Huichen Guo, Li Pan*, Xinsheng Liu*. A novel double-antibody sandwich ELISA based on monoclonal antibodies against the viral spike protein detects porcine deltacoronavirus infection. Microbiology Spectrum 2025, 10.1128/spectrum.02854-24

3.Liping Zhang, Ruiming Yu, Lianshun Wang, Zhongwang Zhang,Yanzhen Lu,Peng Zhou,Yonglu Wang, Huichen Guo, Li Pan*, Xinsheng Liu*. Serial cell culture passaging in vitro led to complete attenuation and changes in the characteristic features of a virulent porcine deltacoronavirus strain. Journal of Virology 2024 Aug 20; 98(8):e0064524.

4.Ruiming Yu, Liping Zhang, Peng Zhou, Zhongwang Zhang, Xiaoqing Liu,Yonglu Wang, Huichen Guo, Li Pan*, Xinsheng Liu*. Evaluation of the immunoprotective effects of porcine deltacoronavirus subunit vaccines. Virology 590 (2024), 109955.

5.Xian Li, Zhong-wang Zhang, Fu-dong Zhang, Jia-hao Li, Jian-liang Lv, Li-Ping Zhang, Kai-ge Zhai, Yong-Lu Wang, Hui-chen Guo, Xin-sheng Liu*, Li Pan*. Double synergic chitosan-coated poly (lactic-co-glycolic) acid nanospheres loaded with nucleic acids as an intranasally administered vaccine delivery system to control the infection of foot-and-mouth disease virus. Antiviral Research 226 (2024) 105900.

6.Kaige Zhai, Zhongwang Zhang, Xinsheng Liu, Jianliang Lv, Liping Zhang, Jiahao Li, Zhongyuan Ma, Yonglu Wang, Huichen Guo, Yongguang Zhang, Li Pan*. Mucosal immune responses induced by oral administration of recombinantLactococcus lactis expressing the S1 protein of PDCoV. Virology 578 (2023) 180–189.

7.Liping Zhang,Ruiming Yu,Zhongwang Zhang,Peng Zhou,Jianliang Lv,Yonglu Wang,Li Pan*,Xinsheng Liu*. Diferences in the pathogenicity of Chinese virulent genotype GIIa and GIIb porcine epidemic diarrhea virus strains and the humoral immune status of one and twomonthold weaned pigs infected with these strains. Archives of Virology (2023) 168:97

8.Zhongwang Zhang,  Fei Yao, Jianliang Lv, Yaozhong Ding, Xinsheng Liu, Liping Zhang, Zhongyuan Ma, Peng Zhou, Yonglu Wang, Huichen Guo, Li Pan*.  Identiffcation of B-cell epitopes on structural proteins VP1 and VP2 of Senecavirus A and development of a multi-epitope recombinant protein vaccine. Virology 582 (2023) 48–56.

9.Zhongyuan Ma, Jianliang Lv, Zhongwang Zhang Li Pan*. Development of an indirect ELISA using a novel linear epitope at the C-terminal region of the VP2 protein to specifcally detect antibodies against Senecavirus A. Virology Journal (2022) 19:204.

10. Jieyi Li, Zhongwang Zhang*, Jianliang Lv, Zhongyuan Ma, Li Pan*, Yongguang Zhang. Global Phosphoproteomics Analysis of IBRS-2 Cells Infected With Senecavirus A. Front. Microbiol. 13:832275. doi: 10.3389/fmicb.2022.832275.

11.Fudong Zhang, Zhongwang Zhang, Xian Li, Jiahao Li, Jianliang Lv, Zhongyuan Ma, Li Pan*. Immune Responses to Orally Administered Recombinant Lactococcus lactis Expressing Multi-Epitope Proteins Targeting M Cells of Foot-and-Mouth Disease Virus. Viruses 2021, 13, 2036. https://doi.org/10.3390/v13102036

12.Zhongyuan Ma,Jianliang Lv, Zhongwang Zhang, Ye Zhao, Li Pan*, Yongguang Zhang*. A chemiluminescence immunoassay for rapid detection of classical swine fever virus E2 antibodies in pig serum samples. Transbound Emerg Dis.2020;00:1-7

13.Huabin Zheng, Li Pan*, Jianliang Lv, Zhongwang Zhang, Yuanyuan Wang, Wenfa Hu, Xinsheng Liu, Peng Zhou, Yonglu Wang, Yongguang Zhang*. Comparison of immune responses in guinea pigs by intranasal delivery with different nanoparticles-loaded FMDV DNA vaccine. Microbial Pathogenesis, 2020, 142:104061

14.Xinsheng Liu, Linlin Qi, Jiangliang Lv,Zhongwang Zhang, Peng Zhou, Zhongyuan Ma, Yonglu Wang, Yongguang Zhang*, Li Pan*. The immune responses to a recombinant Lactococcus lactis oral vaccine against foot-and-mouth disease virus in mice. Biotechnol Lett. http://doi.org/10.1007/s10529-020-02900-6. 2020,May 9.

15.Miao Wang, Li Pan*, Peng Zhou,Jianliang Lv, Yongguang Zhang*. Protection against foot and mouth disease virus in guinea pigs via oral administration of recombinant Lactobacillus plantarum expressing VP1. PlosOne.2015,10(12):e0143750.