Education：
B.Sc. in Biochemistry, 2010, Southwest Jiaotong University, China
Ph.D. in Biophysics, 2015, University of Chinese Academy of Sciences, China
Research Interests：
1. Animal influenza and other major zoonoses
2. Development of novel techniques against major zoonoses
(1) Qian Wang#, Shuai Xu#*, Wentao Shen, Yanli Wei, Lu Han, Zhengxiang Wang, Yingying Yu, Minxuan Liu, Junwen Liu, Guohua Deng, Hualan Chen, Qiyun Zhu. N6-methyladnosine of vRNA facilitates influenza A virus replication by promoting the interaction of vRNA with polymerase proteins, Proceedings of the National Academy of Sciences of the United States of America, 2025, 18;122(11): e2411554122. JCR Q1; IF 2025 = 9.5.
(2) Han Fang#, Mengling Shi#, Cong Wang#, Saiting Zhang, Na Kong, Mengyao Ji, Yan Wang, Yidan Zhou, Qiyun Zhu, Yu Zhang, Shishen Du, Shuai Xu*, Caoqi Lei*. PCSK9 potentiates innate immune response to RNA viruses by preventing AIP4-mediated polyubiquitination and degradation of VISA/MAVS, Proceedings of the National Academy of Sciences of the United States of America, 2025, 122(8): e2412206122. JCR Q1; IF 2025 = 9.5.
(3) Bo Zhang, Lebin Han, Chenying Cui, Jiaxin Huang, Qiyun Zhu, Caoqi Lei*, Shuai Xu*. Influenza a virus NS2 suppresses NFKB/NF-κB signaling to facilitate viral replication by mediating the autophagic-degradation of IKBKG/NEMO, Autophagy, 2026. JCR Q1; IF 2025 = 18.6.
(4) Junwen Liu, Jiaxin Huang, Qian Wang, Yanli Wei, Lebin Han, Xin Li, Caoqi Lei, Guohua Deng, Hualan Chen, Qiyun Zhu*, Shuai Xu*. Tyrosine kinase LYN restricts the replication and virulence of influenza A virus by directly phosphorylating viral nucleoprotein, mBio, 2026, 17(5):e0375925. JCR Q1; IF 2025 = 5.4.
(5) Xingtian Kong, Junwen Liu, Qiyun Zhu, Shuai Xu*. Enolase 1 suppresses influenza A virus replication by blocking the nuclear import of the viral ribonucleoprotein complex, Cellular and Molecular Life Sciences, 2026, 83:127. JCR Q1; IF 2025 = 6.5.
(6) Yuhan Gong#, Junwen Liu#, Wenxuan Ding#, Yuxing Yan#, Xue Hu, Gary Wong, Huaijie Jia, Zhengxiang Wang, Xin Li, Jiayi Chen, Xin Zhang, Chao Shan*, Shuai Xu*, Xiaoxia Wang*. Antiviral activity of Saponin C from Liriope muscari against influenza A virus and SARS-CoV-2, Virologica Sinica, 2026. JCR Q1; IF 2025 = 4.7.
(7) Wentao Shen#, Jie Xu, Zhaoshan Chen, Yanli Wei, Qian Wang, Xiangkun Wang, Xuegang Zhang, Qiyun Zhu*, Shuai Xu*. Broad-spectrum inhibition of influenza A virus replication by blocking the nuclear export of viral ribonucleoprotein complexes. Journal of Virology, 2025. JCR Q2; IF 2025 = 4.1.
(8) Zhengxiang Wang, Wentao Shen, Xuegang Zhang, Yanli Wei, Yingying Du, Yingying Yu, Jing Wang, Qiyun Zhu, Qiaoying Zeng*, Shuai Xu*. HiBiT-tagged influenza A virus: a stable and efficient tool for antiviral reagent screening and vaccine evaluation, Journal of Integrative Agriculture, 2025, 24(10): 4012-4025. JCR Q1; IF 2025 = 5.7.
(9) Yingying Yu, Qian Wang, Yanli Wei, Junwen Liu, Guangwen Wang, Zhengxiang Wang, Wentao Shen, Lu Han, Chengjun Li, Cao-Qi Lei, Shuai Xu*, Qiyun Zhu*. Nucleophosmin 1 inhibits the replication of influenza A virus by competitively binding viral RNA with viral proteins, Virologica Sinica, 2025, 40: 388-400. JCR Q1; IF 2025 = 4.7.
(10) Yingying Du#, Jun Xia#, Zhengxiang Wang, Jie Xu, Yanhong Ji, Yinghong Jin, Ling Pu, Shuai Xu*. Evolution of H6N6 viruses in China between 2014 and 2019 involves multiple reassortment events, Emerging Microbes & Infections, 2024, 13(1): 2341142. JCR Q1; IF 2024 = 7.5.
(11) Bo Zhang#, Shuai Xu#, Minxuan Liu, Yanli Wei, Qian Wang, Wentao Shen, Cao-Qi Lei, Qiyun Zhu*. The nucleoprotein of influenza A virus inhibits the innate immune response by inducing mitophagy, Autophagy, 2023, 19(7): 1916-1933. JCR Q1; IF 2023 = 14.6.
(12) Shuai Xu, Lu Han, Yanli Wei, Bo Zhang, Qian Wang, Junwen Liu, Minxuan Liu, Zhaoshan Chen, Zhengxiang Wang, Hualan Chen, Qiyun Zhu*. MicroRNA-200c-targeted contactin 1 facilitates the replication of influenza A virus by accelerating the degradation of MAVS, PLoS Pathogens, 2022, 18(2): e1010299. JCR Q1; IF 2022 = 6.7.
(13) Wentao Shen, Qian Wang, Zhengxiang Wang, Minxuan Liu, Yingying Du, Lvfeng Yuan, Lu Han, Krzysztof Smietanka, Hualan Chen, Shuai Xu*, Qiyun Zhu*. Specific monoclonal antibodies targeting unique HA epitopes block H7N9 influenza A viral replication, Journal of Virology, 2022, 96(18): e0123822. JCR Q2; IF 2022 = 5.4.
(14) Bo Zhang, Minxuan Liu, Jiaxin Huang, Qiaoying Zeng, Qiyun Zhu*, Shuai Xu*, Hualan Chen. H1N1 influenza A virus protein NS2 inhibits innate immune response by targeting IRF7, Viruses-Basel, 2022, 14(11): 2411. JCR Q2; IF 2022 = 4.7.
(15) Zhaoshan Chen, Yan Zeng, Yanli Wei, Qian Wang, Minxuan Liu, Bo Zhang, Junwen Liu, Qiyun Zhu*, Shuai Xu*. Influenza D virus matrix protein 1 restricts the type I interferon response by degrading TRAF6, Virology, 2022, 568: 1-11. JCR Q3; IF 2022 = 3.7.
(16) Yan Zeng#, Shuai Xu#, Yanli Wei, Xuegang Zhang, Qian Wang, Yane Jia, Wanbing Wang, Lu Han, Zhaoshan Chen, Zhengxiang Wang, Bo Zhang, Hualan Chen, Cao-Qi Lei, Qiyun Zhu*. The PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation, PLoS Pathogens, 2021, 17(2): e1009300. JCR Q1; IF 2021 = 7.464.
