关贵全

联系方式

  • 职  称:动物医学与生物安全学院教授,中国农业科学院兰州兽医研究所外寄生虫与虫媒疫病创新团队首席
  • 联系电话:0931-8342671
  • 邮  箱:guanguiquan@caas.cn

学习经历:

1994.09-1998.07,南京农业大学,农学学士(兽医)

2001.09-2004.07,中国农业科学院研究生院,农学硕士(预防兽医学)

2006.09-2010.03,法国雷恩第一大学,博士(生物学)

工作经历:

1998.07-2003.12,中国农业科学院兰州兽医研究所寄生虫病研究室,研究实习员

2004.01-2008.12,中国农业科学院兰州兽医研究所寄生虫病研究室,助理研究员

2009.01-2013.12,中国农业科学院兰州兽医研究所寄生虫病研究室,副研究员

2014.01-至今,中国农业科学院兰州兽医研究所外寄生虫与虫媒疫病创新团队,研究员

中国农业科学院兰州兽医研究所研究员、博士生导师、外寄生虫与虫媒疫病创新团队首席,兼任中国畜牧兽医学会兽医寄生虫学分会常务理事、中国兽医协会兽医寄生虫病防治分会副会长和中国动物学会原生动物学分会理事。

主要从事虫媒与虫媒病病原生物学、流行病学及诊断检测与防控技术的研究。主持国家自然基金、国家重点研发计划、国家支撑计划、甘肃省甘肃省科技重大专项计划、甘肃省基础研究创新群体项目、中国农业科学院创新工程等10于项,研究成果以第一作者或通讯作者在Int J Parasitol、BMCBiol、Emerg Microbes Infect等期刊发表SCI论文40余篇,参加编/译著作7部,授权国家发明专利40余件,制定国家/农业行业标准4项,获甘肃省自然科学奖二等奖2项、甘肃省科学技术进步奖三等奖2项、中国农业科学院科学技术成果奖二等奖1项、甘肃省农牧渔业丰收奖二等奖各1项、兰州市科学技术进步奖二等奖1项。

主持项目

1. 国家重点研发计划项目子课题(2022YFD1800202A5)2022.11-2025.12,81万元。

2. 甘肃省基础研究创新群体项目(22JR5RA024)2022.10-2025.09,80万元。

3. 国家自然科学基金面上项目(31972701),2020.01-2023.12,57万元。

4. 中国农科院兰州兽医研究所所长基金(LVRI-SZJJ-202105),2021.01-2022.12,80万元。

5. 家畜疫病病原生物学国家重点实验室自主课题(SKLVEB2021CGQD02),2021.01-2022.12,15万元。

6. 分子发育生物学国家重点实验室开放课题(2015-MDB-KF-05),2014.01-2015.12,20万元。

7. 国家支撑计划子课题(2013BAD12B03-03),2013.01-2017.12,70万元。

8. 国家自然科学基金面上项目(31072130),2011.01-2013.12,32万元。

9. 中国农业科学院中央级公益性科研院所基本科研业务费专项资金项目(1610322011022),2011.01-2012.12,25万元。

10. 甘肃省科技重大专项计划项目(0801NKDA033),2008.07-2010.12,50万元。

11. 国家支撑计划子课题(2007BAD40B02-02),2007.12-2010.12,50万元。

第一作者或通讯作者SCI论文:

1. Guan G, Yin H*, Luo J, Lu W, Zhang Q, Gao Y, Lu B. Transmission of Babesia sp to sheep with eld-collected Haemaphysalis qinghaiensis. Parasitol Res. 2002 May;88(13 Suppl 1):S22-24.

2. Guan G, Luo J, Ma M, Yang D, Wang Y, Gao J, Sun H, Liu Z, Liu A, Dang Z, Boulard C, Yin H*. Sero-epidemiological surveillance of hypodermosis in yaks and cattle in north China by ELISA. Vet Parasitol. 2005 Apr 20;129(1-2):133-137.

3. Guan G, Chauvin A, Luo J, Inoue N, Moreau E, Liu Z, Gao J, Thekisoe OM, Ma M, Liu A, Dang Z, Liu J, Ren Q, Jin Y, Sugimoto C, Yin H*. The development and evaluation of a loop-mediated isothermal amplification (LAMP) method for detection of Babesia spp. infective to sheep and goats in China. Exp Parasitol. 2008 Sep;120(1):39-44.

4. Guan G, Ma M, Moreau E, Liu J, Lu B, Bai Q, Luo J, Jorgensen W, Chauvin A, Yin H*. A new ovine Babesia species transmitted by Hyalomma anatolicum anatolicum. Exp Parasitol. 2009 Aug;122(4):261-267.

5. Guan G, Moreau E*, Liu J, Hao X, Ma M, Luo J, Chauvin A, Yin H*. Babesia sp. BQ1 (Lintan): molecular evidence of experimental transmission to sheep by Haemaphysalis qinghaiensis and Haemaphysalis longicornis. Parasitol Int. 2010 Jun;59(2):265-267.

6. Guan G, Moreau E*, Brisseau N, Luo J, Yin H*, Chauvin A. Determination of erythrocyte susceptibility of Chinese sheep (Tan mutton breed) and French sheep (Vendéen breed) to Babesia sp. BQ1 (Lintan) by in vitro culture. Vet Parasitol. 2010 May 28;170(1-2):37-43.

7. Guan G, Chauvin A, Rogniaux H, Luo J, Yin H, Moreau E*. Merozoite proteins from Babesia sp. BQ1 (Lintan) as potential antigens for serodiagnosis by ELISA. Parasitology. 2010 May;137(6):927-38.

8. Guan G, Chauvin A, Yin H, Luo J, Moreau E*. Course of infection by Babesia sp. BQ1 (Lintan) and B. divergens in sheep depends on the production of IFNgamma and IL10. Parasite Immunol. 2010 Feb;32(2):143-52.

9. Guan G, Niu Q, Yang J, Li Y, Gao J, Luo J*, Yin H*. Trypanosoma (Herpetosoma) grosi: first isolation from Chinese striped field mouse (Apodemus agrarius). Parasitol Int. 2011 Jan;60(1):101-4.

10. Guan G, Ma M, Liu A, Ren Q, Wang J, Yang J, Li A, Liu Z, Du P, Li Y, Liu Q, Zhu H, Yin H*, Luo J*. A recently identified ovine Babesia in China: serology and sero-epidemiology. Parasitol Int. 2012 Dec;61(4):532-7.

11. Guan G, Ma M, Liu A, Du P, Ren Q, Li Y, Wang J, Liu Z, Yin H*, Luo J*. Continuous in vitro cultivation of a recently identified Babesia that infects small ruminants in China.Vet Parasitol. 2012 Jul 6;187(3-4):371-8.

12. Guan G, Moreau E*, Liu J, Ma M, Rogniaux H, Liu A, Niu Q, Li Y, Ren Q, Luo J, Chauvin A, Yin H*. BQP35 is a novel member of the intrinsically unstructured protein (IUP) family which is a potential antigen for the sero-diagnosis of Babesia sp. BQ1 (Lintan) infection.Vet Parasitol. 2012 Jul 6;187(3-4):421-30.

13. Wang J, Ma M, Liu A, Ren Q, Li A, Liu Z, Li Y, Yin H, Luo J*, Guan G*. A sero-epidemiological survey of Chinese Babesia motasi for small ruminants in China. Parasitol Res. 2013 Jun;112(6):2387-91.

14. Yang C, Liu J, Li A, Li Y, Liu A, Xie J, Liu G, Yin H, Guan G*, Luo J*. Evaluating the Babesia bovis infection of cattle in China with enzyme-linked immunosorbent assay (ELISA).Acta Parasitol. 2015 Dec;60(4):721-6.

15. Guan G, Liu J, Liu A, Li Y, Niu Q, Gao J, Luo J, Chauvin A, Yin H*, Moreau E*. A member of the HSP90 family from ovine Babesia in China: molecular characterization, phylogenetic analysis and antigenicity. Parasitology. 2015 Sep;142(11):1387-97.

16. Lu H, Ren Q, Li Y, Liu J, Niu Q, Yin H, Meng Q, Guan G*, Luo J*. The efficacies of 5 insecticides against hard ticks Hyalomma asiaticum, Haemaphysalis longicornis and Rhipicephalus sanguineus. Exp Parasitol. 2015 Oct;157:44-7

17. Guan G‡, Korhonen PK‡, Young ND, Koehler AV, Wang T, Li Y, Liu Z, Luo J, Yin H*, Gasser RB*. Genomic resources for a unique, low-virulence Babesia taxon from China. Parasit Vectors. 2016 Oct 27;9(1):564.

18. Niu Q, Liu Z, Yang J, Yu P, Pan Y, Zhai B, Luo J, Guan G*, Yin H*. Expression of sheep pathogen Babesia sp. Xinjiang rhoptry-associated protein 1 and evaluation of its diagnostic potential by enzyme-linked immunosorbent assay. Parasitology. 2016 Dec;143(14):1990-1999.

19. Ma M, Chen Z, Liu A, Ren Q, Liu J, Liu Z, Li Y, Yin H, Guan G*, Luo J*. Biological Parameters of Rhipicephalus (Boophilus) microplus (Acari: Ixodidae) Fed on Rabbits, Sheep, and Cattle. Korean J Parasitol. 2016 Jun;54(3):301-5.

20. Niu Q, Liu Z, Yang J, Yu P, Pan Y, Zhai B, Luo J, Moreau E, Guan G*, Yin H*. Expression analysis and biological characterization of Babesia sp. BQ1 (Lintan) (Babesia motasi-like) rhoptry-associated protein 1 and its potential use in serodiagnosis via ELISA. Parasit Vectors. 2016 May 31;9(1):313.

21. Zhao H, Liu J, Li Y, Yang C, Zhao S, Liu J, Liu A, Liu G, Yin H, Guan G*, Luo J*. Validation of Reference Genes for Quantitative Real-Time PCR in Bovine PBMCs Transformed and Non-transformed by Theileria annulata. Korean J Parasitol. 2016 Feb;54(1):39-46.

22. Li S, Liu J, Liu A, Li Y, Wang S, Wang S, Yin H, Luo J*, Guan G*. Molecular investigation of piroplasma infection in white yaks (Bos grunniens) in Gansu province, China. Acta Trop. 2017 Jul;171:220-225.

23. Yin F, Liu J, Liu A, Li Y, Luo J, Guan G*, Yin H*. Rapid diagnosis of Theileria annulata by recombinase polymerase amplification combined with a lateral flow strip (LF-RPA) in epidemic regions. Vet Parasitol. 2017 Apr 15;237:125-129.

24. Zhao S, Liu J, Zhao H, Li Y, Xie J, Liu A, Hassan MA, Yin H, Guan G*, Luo J*. Evaluating an indirect rMPSP enzyme-linked immunosorbent assay for the detection of bovine Theileria infection in China. Parasitol Res. 2017 Feb;116(2):667-676.

25. Wang T‡, Guan G‡, Korhonen PK‡, Koehler AV, Hall RS, Young ND, Yin H*, Gasser RB*. The apicoplast genomes of two taxonomic units of Babesia from sheep. Vet Parasitol. 2017 Jan 15;233:123-128.

26. Wang T‡, Guan G‡, Korhonen PK‡, Koehler AV, Young ND, Hall RS, Yin H*, Gasser RB*. Mitochondrial genomes of two Babesia taxa from sheep in China as a foundation for population genetic and epidemiological investigations. Infect Genet Evol. 2017 Jan;47:51-55.

27. Yin F, Liu J, Gao S, Liu A, Zhao S, Li S, Wang J, Li Y, Luo J, Guan G*, Yin H*. Exploring the TLR and NLR signaling pathway relevant molecules induced by the Theileria annulata infection in calves. Parasitol Res. 2018 Oct;117(10):3269-3276.

28. Wang J, Yang J, Liu J, Wang X, Xu J, Liu A, Li Y, Liu Z, Ren Q, Luo J, Guan G*, Yin H*. Molecular detection and genetic diversity of Theileria orientalis in cattle in China. Parasitol Res. 2018 Dec;117(12):3689-3694.

29. Yin F, Liu Z, Liu J, Liu A, Salih DA, Li Y, Liu G, Luo J, Guan G*, Yin H*. Population Genetic Analysis of Theileria annulata from Six Geographical Regions in China, Determined on the Basis of Micro- and Mini-satellite Markers. Front Genet. 2018 Feb 19;9:50.

30. Wang J, Liu A, Zhang S, Gao S, Rashid M, Li Y, Liu J, Ma Q, Li Z, Liu Z, Luo J, Guan G*, Yin H*. High resolution melting analysis of the 18S rRNA gene for the rapid diagnosis of bovine babesiosis. Parasit Vectors. 2019 Nov 6;12(1):523.

31. Wang X, Wang J, Liu J, Liu A, He X, Xu J, Li Z, Zhao S, Li Y, Yin H, Luo J, Guan G*. Comparative analysis of apicoplast genomes of Babesia infective to small ruminants in China. Parasit Vectors. 2019 Jun 24;12(1):312.

32. Wang J, Liu J, Yang J, Liu Z, Wang X, Li Y, Luo J, Guan G*, Yin H*. Molecular detection and genetic diversity of Babesia canis canis in pet dogs in Henan Province, China. Parasitol Int. 2019 Aug;71:37-40.

33. Wang J, Liu J, Yang J, Wang X, Li Z, Jianlin X, Li X, Xiang Q, Li Y, Liu Z, Luo J, Guan G*, Yin H*. The first molecular detection and genetic diversity of Babesia caballi and Theileria equi in horses of Gansu province, China. Ticks Tick Borne Dis. 2019 Apr;10(3):528-532.

34. Wang J#, Zhang S, Yang J, Liu J, Zhang D, Li Y, Luo J, Guan G*, Yin H*. Babesia divergens in human in Gansu province, China. Emerg Microbes Infect. 2019;8(1):959-961.

35. Ma Q, Liu J, Li Z, Xiang Q, Wang J, Liu A, Li Y, Yin H, Guan G*, Luo J*. Clinical and Pathological Studies on Cattle Experimentally Infected with Theileria annulata in China. Pathogens. 2020 Sep 3;9(9):727.

36. Wang J, Wang X, Sun H, Lv Z, Li Y, Luo J, Guan G*, Yin H*. Molecular evidence of piroplasm infection in companion animals in Hunan Province, China. BMC Vet Res. 2020 Aug 17;16(1):297.

37. Wang X, Wang J, Liu J, Liu A, He X, Xiang Q, Li Y, Yin H, Luo J, Guan G*. Insights into the phylogenetic relationships and drug targets of Babesia isolates infective to small ruminants from the mitochondrial genomes. Parasit Vectors. 2020 Jul 29;13(1):378.

38. Wang J, Gao S, Zhang S, He X, Liu J, Liu A, Li Y, Liu G, Luo J, Guan G*, Yin H*. Rapid detection of Babesia motasi responsible for human babesiosis by cross-priming amplification combined with a vertical flow. Parasit Vectors. 2020 Jul 29;13(1):377.

39. Wang J, Yang J, Gao S, Wang X, Sun H, Lv Z, Li Y, Liu A, Liu J, Luo J, Guan G*, Yin H*. Genetic Diversity of Babesia bovis MSA-1, MSA-2b and MSA-2c in China. Pathogens. 2020 Jun 15;9(6):473.

40. Wang J, Yang J, Gao S, Liu A, Rashid M, Li Y, Liu Z, Liu J, Liu G, Luo J, Guan G*, Yin H*. Rapid detection and differentiation of Theileria annulata, T. orientalis and T. sinensis using high-resolution melting analysis. Ticks Tick Borne Dis. 2020 Jan;11(1):101312.

41. Wang J, Chen K, Ren Q, Zhang Y, Liu J, Wang G, Liu A, Li Y, Liu G, Luo J, Miao W, Xiong J*, Yin H*, Guan G*. Systematic Comparison of the Performances of De Novo Genome Assemblers for Oxford Nanopore Technology Reads From Piroplasm. Front Cell Infect Microbiol. 2021;11:644983.

42. Wang J, Wang X, Guan G*, Yang J, Liu J, Liu A, Li Y, Luo J, Yin H*. Stable transfection system for Babesia sp. Xinjiang. Parasit Vectors. 2021;14(1):463.

43. Wang J, Gao S, Yang J, Liu J, Li Y, Luo J, Guan G*, Yin H*. Cross-priming amplification targeting the 18S rRNA gene for the rapid diagnosis of Babesia bovis infection. Ticks Tick Borne Dis. 2021;12(4):101713.

44. Xu J, Wang J, Li Z, He X, Zhao S, Ma Q, Li X, Liu J, Liu A, Li Y, Yin H, Luo J*, Guan G*. A universal ELISA assay for detecting six strains of ovine Babesia species in China. Vet Parasitol. 2021;300:109616.

45. Wang X, Wang J, Liu J, Yang J, Lv Z, Liu A, Li Y, Li Y, Lan H, Liu G, Luo J, Guan G*. Yin H*. Establishment of a transient transfection system for Babesia sp. Xinjiang using homologous promoters. Parasitol Res. 2021;120(10):3625-3630.

46. Wang J*, Chen K, Yang J, Zhang S, Li Y, Liu G, Luo J, Yin H, Wang G*, Guan G*. Comparative genomic analysis of Babesia duncani responsible for human babesiosis. BMC Biol. 2022;20(1):153.

47. Zhang S, Wang J, Li X, Wang Y, Nian Y, You C*, Zhang D*, Guan G*. Babeisa duncani infection alters gut microbiota profile in hamsters. Parasites Hosts Dis. 2023;61(1):42-52.

48. Wang J*, Chen K, Ren Q, Zhang S, Yang J, Wang Y, Nian Y, Li X, Liu G, Luo J, Yin H*, Guan G*. Comparative genomics reveals unique features of two Babesia motasi subspecies: Babesia motasi lintanensis and Babesia motasi hebeiensis. Int J Parasitol. 2023;53(5-6):265-283.

 

专利:

1. 殷宏、罗建勋、关贵全、杨吉飞、牛庆丽、马米玲、高金亮、刘志杰、李有全、刘军龙; 任巧云. 蜱体内检测莱姆病病原的检测试剂盒. 国家发明专利,ZL200910005012.220121017

2. 殷宏、罗建勋、关贵全、牛庆丽、杨吉飞. 区分莱姆病病原基因型的试剂. 国家发明专利,ZL200910258201.02013320

3. 刘爱红、关贵全、刘军龙、谢俊仁、牛庆丽、罗建勋、殷宏. 一种检测羊巴贝斯虫的实时荧光定量PCR试剂盒. 国家发明专利,ZL201510011313.1. 20171031

4. 关贵全、何欣、王锦明、刘军龙、刘爱红、李有全、赵帅阳、殷宏、罗建勋. 一种检测多种羊巴贝斯虫的方法及检测试剂. 国家发明专利,ZL201710458814.320201117

5. 王锦明,关贵全,杨吉飞,刘军龙,李有全,刘志杰,殷宏,罗建勋. 一种鉴别检测牛巴贝斯虫的试剂盒及检测方法. 国家发明专利. ZL201811565936.3. 202193

6. 王锦明,关贵全,刘军龙,李有全,刘爱红,杨吉飞,刘志杰,殷宏,罗建勋. 一种检测牛巴贝斯虫的引物组、探针及试剂盒. 国家发明专利. 2022.02.21. ZL201910129341.1.

7. 王锦明,关贵全,刘军龙,刘爱红,李有全,高闪电,田占成,独军政,任巧云,罗金,陈泽,刘光远,杨吉飞,刘志杰,殷宏. 一种牛泰勒虫检测试剂盒. 国家发明专利. 2022.05.31. ZL201910254485.X.

8. 王锦明,关贵全,牛庆丽;刘军龙,任巧云,李有全,刘爱红,刘志杰,殷宏,罗建勋,刘光远,杨吉飞,陈泽,田占成. 一种可用于羊泰勒虫检测的引物及试剂盒. 国家发明专利. 2022.05.27. ZL201910296143.4.

9. 马全英,关贵全,刘学荣,李有全,刘军龙,刘爱红,李菁,刘兆弼,殷宏,罗建勋,刘光远,杨吉飞.一种环形泰勒虫病疫苗保护剂及制备方法. 国家发明专利. 2021.12.10. ZL201811057795.4.

标准:

1. 殷宏、罗建勋、关贵全. 牛皮蝇蛆病诊断技术,国家标准,GBT 22329-20082008822日发布,2008121日实施.

2. 罗建勋、刘军龙、关贵全、殷宏、刘爱红、李有全. 牛泰勒虫病诊断技术,农业行业标准,NY/T3464-2019201981日发布,2019111日实施.

3. 殷宏、关贵全、刘爱红、刘军龙、罗建勋. 牛巴贝斯虫病诊断技术,国家标准,GB/T 41556-2022,2022711日发布,202321日实施.

4. 殷宏、刘军龙、关贵全、李有全、罗建勋. 羊泰勒虫病诊断技术,国家标准,GB/T 42117-2022,20221230日发布,202371日实施.

 

科研奖励:

1. 孙明、马超、张伟、姜金玲、魏春梅、关贵全、王淑芳、王多全、赵鑫、程生忠、聂英、郭精福、唐戬运、张海丽、魏玲丽. 武威市蜱与梨形虫病流行现状调查及防控技术研究. 甘肃省农牧渔业丰收奖二等奖,2023915

2. 杨吉飞、牛庆丽、刘志杰、殷宏、关贵全. 几中重要新发蜱媒人畜共患病原菌的发现、鉴定与溯源研究. 甘肃省自然科学奖二等奖(2021-Z2-005-R5,202269

3. 殷宏、罗建勋、关贵全、刘光远、李有全. 动物梨形虫种类厘定及流行要素. 甘肃省自然科学奖二等奖,2009-Z2-005-R3201047

4. 罗建勋、殷宏、刘光远、关贵全、李世恩、张西臣、刘志杰、刘爱红、吕文顺、白启、张林、鲁炳义、党志胜. 牛巴贝斯虫病病原学特征、分子分类学及防治技术的研究. 甘肃省科技进步奖三等奖(2005-3-042/420051231日)和中国农业科学院科学技术成果二等奖(2006-24-42006616日)

5. 殷宏、罗建勋、关贵全、高玉龙、马米玲、鲁炳义、刘光远、王文彪、惠继龙、杜宏德、马登录、郭淑珍、张其才、吕文顺、白启、惠禹、袁正朴、袁改玲. 羊的泰勒虫生物学特性、分子分类学及防治技术的研究. 甘肃省科技进步奖三等奖,2002-3-051/320034

6. 殷宏、罗建勋、关贵全、鲁炳义、党志胜、常华山、惠继龙、盖文革、李发新、刘志杰、刘爱红、张慧婷、马米玲、杨东英、王艳华、高金亮、任巧云、聂其成、常增荣、惠禹. 牛皮蝇蛆病环境友好控制关键技术. 兰州市科学技术进步奖二等奖,2008-2-10-32008121

 

学术兼职:

中国畜牧兽医学会兽医寄生虫学分会常务理事、中国兽医协会兽医寄生虫病防治分会副会长和中国动物学会原生动物学分会理事。